PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4103)
Related Products (4103)
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PROTAC Linkers Isoform Comparison
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m-PEG12-Br
0 ImagesCat. No.: HY-141378CAS No.: 1620461-89-3
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2-(4-(2-Aminoethyl)piperazin-1-yl)ethan-1-ol
0 ImagesCat. No.: HY-W318996CAS No.: 20542-08-9
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Hydroxy-PEG7-CH2-Boc
0 ImagesCat. No.: HY-133310CAS No.: 2378049-28-4Synonyms: HO-PEG7-CH2COOtBu
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7-((Tert-butyldimethylsilyl)oxy)heptan-1-ol
0 ImagesCat. No.: HY-W970096CAS No.: 126696-08-0
![Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane](https://file.medchemexpress.com/product_pic/hy-168075.gif "Click to View Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane Product Detail")
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N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5
0 ImagesCat. No.: HY-141075CAS No.: 2107273-72-1
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tert-Butyl (3-aminopropoxy)carbamate
0 ImagesCat. No.: HY-W419952CAS No.: 228245-16-7
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Benzyl 2-cyanoacetate
0 ImagesCat. No.: HY-W095744CAS No.: 14447-18-8Synonyms: Benzyl cyanoacetate
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(S)-tert-Butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate
0 ImagesCat. No.: HY-W102130CAS No.: 1010446-31-7
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3-(Piperidin-4-yl)propan-1-amine
0 ImagesCat. No.: HY-W561948CAS No.: 860229-31-8
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tert-Butyl 18-bromooctadecanoate
0 ImagesCat. No.: HY-W251676CAS No.: 1199580-32-9
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tert-Butyl ((3-aminocyclobutyl)methyl)carbamate
0 ImagesCat. No.: HY-W265332CAS No.: 1334499-53-4
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N,N'-Di-Boc-1,4-butanediamine
0 ImagesCat. No.: HY-W101720CAS No.: 33545-97-0
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tert-Butyltrimethylsilane-PEG2-NH2
0 ImagesCat. No.: HY-W460248CAS No.: 215297-17-9
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3-(Aminomethyl)cyclobutanecarboxylic acid hydrochloride
0 ImagesCat. No.: HY-W052547CAS No.: 1818847-68-5
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(S,R,S)-Ahpc-PEG6-azide
0 ImagesCat. No.: HY-W590583CAS No.: 2767219-19-0(S, R, S)-AHPC-PEG6-Azide is a click chemistry PROTAC linker that incorporates an E3 ligase ligand with a PEG6 arm to empower PROTAC research & discovery. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Azide enables click chemistry with alkyne, DBCO, or BCN molecule.
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Cyano-PEG4-cyano
0 ImagesCat. No.: HY-W105836CAS No.: 57741-46-5
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7-Oxoheptanoic acid methyl ester
0 ImagesCat. No.: HY-W639905CAS No.: 35376-00-2
